Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification

por Howard, Beatrice, Panchal, Heena, McCarthy, Afshan, Ashworth, Alan
Publicado 2005

Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis

por Francis, Jeffrey C., McCarthy, Afshan, Thomsen, Martin K., Ashworth, Alan, Swain, Amanda
Publicado 2010

A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake

por East, Lucy, McCarthy, Afshan, Wienke, Dirk, Sturge, Justin, Ashworth, Alan, Isacke, Clare M.
Publicado 2003

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

por Sourisseau, Tony, Maniotis, Despina, McCarthy, Afshan, Tang, Chan, Lord, Christopher J, Ashworth, Alan, Linardopoulos, Spiros
Publicado 2010

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

por Sakamoto, Kei, McCarthy, Afshan, Smith, Darrin, Green, Kevin A, Grahame Hardie, D, Ashworth, Alan, Alessi, Dario R
Publicado 2005

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

por Martin, Sarah A, McCarthy, Afshan, Barber, Louise J, Burgess, Darren J, Parry, Suzanne, Lord, Christopher J, Ashworth, Alan
Publicado 2009

Tumor suppressor role of phospholipase Cε in Ras-triggered cancers

por Martins, Marta, McCarthy, Afshan, Baxendale, Rhona, Guichard, Sabrina, Magno, Lorenza, Kessaris, Nicoletta, El-Bahrawy, Mona, Yu, Philipp, Katan, Matilda
Publicado 2014

Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine

por Shorning, Boris Y., Zabkiewicz, Joanna, McCarthy, Afshan, Pearson, Helen B., Winton, Douglas J., Sansom, Owen J., Ashworth, Alan, Clarke, Alan R.
Publicado 2009

Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine

por Shorning, Boris Y., Zabkiewicz, Joanna, McCarthy, Afshan, Pearson, Helen B., Winton, Douglas J., Sansom, Owen J., Ashworth, Alan, Clarke, Alan R.
Publicado 2009

Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine

por Shorning, Boris Y., Zabkiewicz, Joanna, McCarthy, Afshan, Pearson, Helen B., Winton, Douglas J., Sansom, Owen J., Ashworth, Alan, Clarke, Alan R.
Publicado en PLoS One (2019)

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

por Mendes-Pereira, Ana M, Martin, Sarah A, Brough, Rachel, McCarthy, Afshan, Taylor, Jessica R, Kim, Jung-Sik, Waldman, Todd, Lord, Christopher J, Ashworth, Alan
Publicado 2009

Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF

por Martins, Marta, Warren, Sean, Kimberley, Christopher, Margineanu, Anca, Peschard, Pascal, McCarthy, Afshan, Yeo, Maggie, Marshall, Christopher J., Dunsby, Christopher, French, Paul M. W., Katan, Matilda
Publicado 2012

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

por Kümper, Sandra, Mardakheh, Faraz K, McCarthy, Afshan, Yeo, Maggie, Stamp, Gordon W, Paul, Angela, Worboys, Jonathan, Sadok, Amine, Jørgensen, Claus, Guichard, Sabrina, Marshall, Christopher J
Publicado en eLife (2016)

Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

por Alanis-Lobato, Gregorio, Zohren, Jasmin, McCarthy, Afshan, Fogarty, Norah M. E., Kubikova, Nada, Hardman, Emily, Greco, Maria, Wells, Dagan, Turner, James M. A., Niakan, Kathy K.
Publicado en Proc Natl Acad Sci U S A (2021)

A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer

por Graeser, Monika, McCarthy, Afshan, Lord, Christopher J, Savage, Kay, Hills, Margaret, Salter, Janine, Orr, Nicholas, Parton, Marina, Smith, Ian E, Reis-Filho, Jorge S, Dowsett, Mitch, Ashworth, Alan, Turner, Nicholas
Publicado 2010

A Screen for Morphological Complexity Identifies Regulators of Switch-like Transitions between Discrete Cell Shapes

por Yin, Zheng, Sadok, Amine, Sailem, Heba, McCarthy, Afshan, Xia, Xiaofeng, Li, Fuhai, Garcia, Mar Arias, Evans, Louise, Barr, Alexis, Perrimon, Norbert, Marshall, Christopher J, Wong, Stephen T.C., Bakal, Chris
Publicado 2013

The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

por ElInati, Elias, Zielinska, Agata P., McCarthy, Afshan, Kubikova, Nada, Maciulyte, Valdone, Mahadevaiah, Shantha, Sangrithi, Mahesh N., Ojarikre, Obah, Wells, Dagan, Niakan, Kathy K., Schuh, Melina, Turner, James M. A.
Publicado en Nat Commun (2020)

TRF2-independent chromosome end protection during pluripotency

por Ruis, Phil, Van Ly, David, Borel, Valerie, Kafer, Georgia R., McCarthy, Afshan, Howell, Steven, Blassberg, Robert, Snijders, Ambrosius P., Briscoe, James, Niakan, Kathy K., Marzec, Paulina, Cesare, Anthony J., Boulton, Simon J.
Publicado en Nature (2021)

Initiation of a conserved trophectoderm program in human, cow and mouse embryos

por Gerri, Claudia, McCarthy, Afshan, Alanis-Lobato, Gregorio, Demtschenko, Andrej, Bruneau, Alexandre, Loubersac, Sophie, Fogarty, Norah M. E., Hampshire, Daniel, Elder, Kay, Snell, Phil, Christie, Leila, David, Laurent, Van de Velde, Hilde, Fouladi-Nashta, Ali A., Niakan, Kathy K.
Publicado en Nature (2020)

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

por Wamaitha, Sissy E., Grybel, Katarzyna J., Alanis-Lobato, Gregorio, Gerri, Claudia, Ogushi, Sugako, McCarthy, Afshan, Mahadevaiah, Shantha K., Healy, Lyn, Lea, Rebecca A., Molina-Arcas, Miriam, Devito, Liani G., Elder, Kay, Snell, Phil, Christie, Leila, Downward, Julian, Turner, James M. A., Niakan, Kathy K.
Publicado en Nat Commun (2020)