Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis

Epidemiological studies have shown that one of the strongest risk factors for prostate cancer is a family history of the disease, suggesting that inherited factors play a major role in prostate cancer susceptibility. Germline mutations in BRCA2 predispose to breast and ovarian cancer with its predom...

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Bibliographic Details
Main Authors: Francis, Jeffrey C., McCarthy, Afshan, Thomsen, Martin K., Ashworth, Alan, Swain, Amanda
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891704/
https://ncbi.nlm.nih.gov/pubmed/20585617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000995
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