Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

The protein kinase Aurora-A is a major regulator of the cell cycle that orchestrates mitotic entry and is required for the assembly of a functional mitotic spindle. Overexpression of Aurora-A has been strongly linked with oncogenesis and this has led to considerable efforts at therapeutic targeting...

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Main Authors: Sourisseau, Tony, Maniotis, Despina, McCarthy, Afshan, Tang, Chan, Lord, Christopher J, Ashworth, Alan, Linardopoulos, Spiros
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377280/
https://ncbi.nlm.nih.gov/pubmed/20373286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201000068
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