Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks

Vosaroxin (formerly voreloxin) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, inducing site-selective double-strand breaks (DSB), G2 arrest and apoptosis. Objective responses and complete remissions were observed in phase 2 studies of vosarox...

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Main Authors: Hawtin, Rachael Elizabeth, Stockett, David Elliot, Wong, Oi Kwan, Lundin, Cecilia, Helleday, Thomas, Fox, Judith Ann
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2010
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248135/
https://ncbi.nlm.nih.gov/pubmed/21317456
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