Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation

Ionizing radiation (IR) produces direct two-ended DNA double-strand breaks (DSBs) primarily repaired by non-homologous end joining (NHEJ). It is, however, well established that homologous recombination (HR) is induced and required for repair of a subset of DSBs formed following IR. Here, we find tha...

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Bibliographic Details
Main Authors: Groth, Petra, Orta, Manuel Luís, Elvers, Ingegerd, Majumder, Muntasir Mamun, Lagerqvist, Anne, Helleday, Thomas
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413124/
https://ncbi.nlm.nih.gov/pubmed/22505579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks315
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