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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Recent studies indicate that the LKB1 tumour suppressor protein kinase is the major ‘upstream' activator of the energy sensor AMP-activated protein kinase (AMPK). We have used mice in which LKB1 is expressed at only ∼10% of the normal levels in muscle and most other tissues, or that lack LKB1 e...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1142598/ https://ncbi.nlm.nih.gov/pubmed/15889149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600667 |
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