Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

Recent studies indicate that the LKB1 tumour suppressor protein kinase is the major ‘upstream' activator of the energy sensor AMP-activated protein kinase (AMPK). We have used mice in which LKB1 is expressed at only ∼10% of the normal levels in muscle and most other tissues, or that lack LKB1 e...

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Main Authors: Sakamoto, Kei, McCarthy, Afshan, Smith, Darrin, Green, Kevin A, Grahame Hardie, D, Ashworth, Alan, Alessi, Dario R
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142598/
https://ncbi.nlm.nih.gov/pubmed/15889149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600667
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