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Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation
Methotrexate (MTX) is a widely used anti-cancer and anti-rheumatic drug that has been postulated to protect against metabolic risk factors associated with type 2 diabetes mellitus, although the mechanism remains unknown. MTX inhibits 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase /...
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| Опубликовано в: : | Diabetes |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5703413/ https://ncbi.nlm.nih.gov/pubmed/25338814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0508 |
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