Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

Methotrexate (MTX) is a widely used anti-cancer and anti-rheumatic drug that has been postulated to protect against metabolic risk factors associated with type 2 diabetes mellitus, although the mechanism remains unknown. MTX inhibits 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase /...

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Publicado en:Diabetes
Main Authors: Pirkmajer, Sergej, Kulkarni, Sameer S., Tom, Robby Z., Fyffe, Fiona A., Hawley, Simon A., Hardie, D. Grahame, Zierath, Juleen R., Chibalin, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703413/
https://ncbi.nlm.nih.gov/pubmed/25338814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0508
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