Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells

The importance of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) as effectors of metformin (Met) action on glucose uptake (GU) in skeletal muscle cells was investigated. GU in L6 myotubes was stimulated 2-fold following 16 h of Met treatment and acutely enhanced by insulin in an addi...

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Autors principals: Turban, Sophie, Stretton, Clare, Drouin, Olivier, Green, Charlotte J., Watson, Maria L., Gray, Alexander, Ross, Fiona, Lantier, Louise, Viollet, Benoit, Hardie, D. Grahame, Marette, Andre, Hundal, Harinder S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370192/
https://ncbi.nlm.nih.gov/pubmed/22511782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.330746
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