Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

The tumour suppressor gene, phosphatase and tensin homolog (PTEN), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in...

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Detalhes bibliográficos
Main Authors: Mendes-Pereira, Ana M, Martin, Sarah A, Brough, Rachel, McCarthy, Afshan, Taylor, Jessica R, Kim, Jung-Sik, Waldman, Todd, Lord, Christopher J, Ashworth, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378149/
https://ncbi.nlm.nih.gov/pubmed/20049735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900041
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