Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

The tumour suppressor gene, phosphatase and tensin homolog (PTEN), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in...

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Hlavní autoři: Mendes-Pereira, Ana M, Martin, Sarah A, Brough, Rachel, McCarthy, Afshan, Taylor, Jessica R, Kim, Jung-Sik, Waldman, Todd, Lord, Christopher J, Ashworth, Alan
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2009
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378149/
https://ncbi.nlm.nih.gov/pubmed/20049735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900041
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