Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

The tumour suppressor gene, phosphatase and tensin homolog (PTEN), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Mendes-Pereira, Ana M, Martin, Sarah A, Brough, Rachel, McCarthy, Afshan, Taylor, Jessica R, Kim, Jung-Sik, Waldman, Todd, Lord, Christopher J, Ashworth, Alan
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2009
Matèries:
Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378149/
https://ncbi.nlm.nih.gov/pubmed/20049735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900041
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars