Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

The tumour suppressor gene, phosphatase and tensin homolog (PTEN), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in...

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Bibliografiske detaljer
Main Authors: Mendes-Pereira, Ana M, Martin, Sarah A, Brough, Rachel, McCarthy, Afshan, Taylor, Jessica R, Kim, Jung-Sik, Waldman, Todd, Lord, Christopher J, Ashworth, Alan
Format: Artigo
Sprog:Inglês
Udgivet: WILEY-VCH Verlag 2009
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378149/
https://ncbi.nlm.nih.gov/pubmed/20049735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900041
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