Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

The tumour suppressor gene, phosphatase and tensin homolog (PTEN), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in...

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Bibliographische Detailangaben
Hauptverfasser: Mendes-Pereira, Ana M, Martin, Sarah A, Brough, Rachel, McCarthy, Afshan, Taylor, Jessica R, Kim, Jung-Sik, Waldman, Todd, Lord, Christopher J, Ashworth, Alan
Format: Artigo
Sprache:Inglês
Veröffentlicht: WILEY-VCH Verlag 2009
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378149/
https://ncbi.nlm.nih.gov/pubmed/20049735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900041
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