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PARP Inhibitors: The First Synthetic Lethal Targeted Therapy
PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a genetic concept proposed nearly a century ago. Tumors arising in patients who carry germline mutations in either BRCA1 or BRCA2 are sens...
שמור ב:
| הוצא לאור ב: | Science |
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| Main Authors: | , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6175050/ https://ncbi.nlm.nih.gov/pubmed/28302823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aam7344 |
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