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A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
Inhibitors of poly (ADP-ribose)-polymerase-1 (PARP) are highly lethal to cells with deficiencies in BRCA1, BRCA2 or other components of the homologous recombination pathway. This has led to PARP inhibitors entering clinical trials as a potential therapy for cancer in carriers of BRCA1 and BRCA2 muta...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374839/ https://ncbi.nlm.nih.gov/pubmed/18388863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.61 |
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