A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

Inhibitors of poly (ADP-ribose)-polymerase-1 (PARP) are highly lethal to cells with deficiencies in BRCA1, BRCA2 or other components of the homologous recombination pathway. This has led to PARP inhibitors entering clinical trials as a potential therapy for cancer in carriers of BRCA1 and BRCA2 muta...

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Bibliografiske detaljer
Main Authors: Turner, Nicholas C, Lord, Christopher J, Iorns, Elizabeth, Brough, Rachel, Swift, Sally, Elliott, Richard, Rayter, Sydonia, Tutt, Andrew N, Ashworth, Alan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374839/
https://ncbi.nlm.nih.gov/pubmed/18388863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.61
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