An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer

Poor prognosis oestrogen receptor positive breast cancer is characterized by the presence of high-level focal amplifications. We utilized a focused siRNA screen in 14 breast cancer cell lines to define genes that were pathogenic in three genomic regions focally amplified in oestrogen receptor positi...

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Bibliographic Details
Main Authors: Garcia-Murillas, Isaac, Sharpe, Rachel, Pearson, Alex, Campbell, James, Natrajan, Rachael, Ashworth, Alan, Turner, Nicholas C
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970970/
https://ncbi.nlm.nih.gov/pubmed/23752180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.202
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