High Sensitivity RT-qPCR Assay of Nonlabeled siRNA in Small Blood Volume for Pharmacokinetic Studies: Application to Survivin siRNA

RNAi therapeutics provide an opportunity to correct faulty genes, and several RNAi have entered clinical evaluation. The existing quantification methods typically use radioactivity- or fluorescence-labeled RNAi, require large blood volumes, and/or have a limited dynamic detection range. We establish...

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Udgivet i:AAPS J
Main Authors: Yeung, Bertrand Z., Lu, Ze, Wientjes, Guillaume M., Au, Jessie L.-S.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627457/
https://ncbi.nlm.nih.gov/pubmed/26286676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9812-y
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