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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
The tumour suppressor gene, phosphatase and tensin homolog (PTEN), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
WILEY-VCH Verlag
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378149/ https://ncbi.nlm.nih.gov/pubmed/20049735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900041 |
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