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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

Transformation by oncogenic Ras requires the function of the Rho family GTPases. We find that Ras-transformed cells have elevated levels of RhoA-GTP, which functions to inhibit the expression of the cell cycle inhibitor p21/Waf1. These high levels of Rho-GTP are not a direct consequence of Ras signa...

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Hlavní autoři: Sahai, Erik, Olson, Michael F., Marshall, C.J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC145410/
https://ncbi.nlm.nih.gov/pubmed/11179220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.4.755
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