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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
Transformation by oncogenic Ras requires the function of the Rho family GTPases. We find that Ras-transformed cells have elevated levels of RhoA-GTP, which functions to inhibit the expression of the cell cycle inhibitor p21/Waf1. These high levels of Rho-GTP are not a direct consequence of Ras signa...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC145410/ https://ncbi.nlm.nih.gov/pubmed/11179220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.4.755 |
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