Functional Cross-talk between Ras and Rho Pathways: A Ras-SPECIFIC GTPase-ACTIVATING PROTEIN (p120RasGAP) COMPETITIVELY INHIBITS THE RhoGAP ACTIVITY OF DELETED IN LIVER CANCER (DLC) TUMOR SUPPRESSOR BY MASKING THE CATALYTIC ARGININE FINGER

The three deleted in liver cancer genes (DLC1–3) encode Rho-specific GTPase-activating proteins (RhoGAPs). Their expression is frequently silenced in a variety of cancers. The RhoGAP activity, which is required for full DLC-dependent tumor suppressor activity, can be inhibited by the Src homology 3...

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Main Authors: Jaiswal, Mamta, Dvorsky, Radovan, Amin, Ehsan, Risse, Sarah L., Fansa, Eyad K., Zhang, Si-Cai, Taha, Mohamed S., Gauhar, Aziz R., Nakhaei-Rad, Saeideh, Kordes, Claus, Koessmeier, Katja T., Cirstea, Ion C., Olayioye, Monilola A., Häussinger, Dieter, Ahmadian, Mohammad R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945346/
https://ncbi.nlm.nih.gov/pubmed/24443565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527655
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