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DLC1 Activation Requires Lipid Interaction through a Polybasic Region Preceding the RhoGAP Domain
Deleted in Liver Cancer 1 (DLC1) is a GTPase-activating protein (GAP) with specificity for RhoA, RhoB, and RhoC that is frequently deleted in various tumor types. By inactivating these small GTPases, DLC1 controls actin cytoskeletal remodeling and biological processes such as cell migration and prol...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762136/ https://ncbi.nlm.nih.gov/pubmed/19710422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-03-0247 |
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