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Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation
Sprouty2 is a feedback regulator that controls the Ras-Raf-MEK-ERK mitogen-activated protein kinase (MAPK) pathway at multiple levels, one way being through direct interaction with Raf kinases. Consistent with a role as a tumor suppressor, Sprouty2 expression is often down-regulated in human cancers...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762204/ https://ncbi.nlm.nih.gov/pubmed/19690147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4447 |
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