Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

RAF kinases are key players in the MAPK signaling pathway and are important targets for personalized cancer therapy. RAF dimerization is part of the physiological activation mechanism, together with phosphorylation, and is known to convey resistance to RAF inhibitors. Herein, molecular dynamics simu...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Jambrina, Pablo G., Rauch, Nora, Pilkington, Ruth, Rybakova, Katja, Nguyen, Lan K., Kholodenko, Boris N., Buchete, Nicolae‐Viorel, Kolch, Walter, Rosta, Edina
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2015
Assuntos:
Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736688/
https://ncbi.nlm.nih.gov/pubmed/26644280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201509272
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