RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF

Lignende værker

• The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
  af: Joseph, Eric W., et al.
  Udgivet: (2010)
• RAF inhibitor PLX8394 selectively disrupts BRAF-dimers and RAS-independent BRAF mutant-driven signaling
  af: Yao, Zhan, et al.
  Udgivet: (2018)
• An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling
  af: Karoulia, Zoi, et al.
  Udgivet: (2016)
• RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
  af: Poulikakos, Poulikos I., et al.
  Udgivet: (2011)
• Inhibitors of BRAF dimers using an allosteric site
  af: Cotto-Rios, Xiomaris M., et al.
  Udgivet: (2020)