An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling

The complex biochemical effects of RAF inhibitors account for both the effectiveness and mechanisms of resistance to these drugs, but a unified mechanistic model has been lacking. Here we show that RAF inhibitors exert their effects via two distinct allosteric mechanisms. Drug resistance due to dime...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Karoulia, Zoi, Wu, Yang, Ahmed, Tamer A., Xin, Qisheng, Bollard, Julien, Krepler, Clemens, Wu, Xuewei, Zhang, Chao, Bollag, Gideon, Herlyn, Meenhard, Fagin, James A., Lujambio, Amaia, Gavathiotis, Evripidis, Poulikakos, Poulikos I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021590/
https://ncbi.nlm.nih.gov/pubmed/27523909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.06.024
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