The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

Tumors with mutant BRAF and some with mutant RAS are dependent upon ERK signaling for proliferation, and their growth is suppressed by MAPK/ERK kinase (MEK) inhibitors. In contrast, tumor cells with human EGF receptor (HER) kinase activation proliferate in a MEK-independent manner. These findings ha...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Joseph, Eric W., Pratilas, Christine A., Poulikakos, Poulikos I., Tadi, Madhavi, Wang, Weiqing, Taylor, Barry S., Halilovic, Ensar, Persaud, Yogindra, Xing, Feng, Viale, Agnes, Tsai, James, Chapman, Paul B., Bollag, Gideon, Solit, David B., Rosen, Neal
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930420/
https://ncbi.nlm.nih.gov/pubmed/20668238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008990107
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы