The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

Tumors with mutant BRAF and some with mutant RAS are dependent upon ERK signaling for proliferation, and their growth is suppressed by MAPK/ERK kinase (MEK) inhibitors. In contrast, tumor cells with human EGF receptor (HER) kinase activation proliferate in a MEK-independent manner. These findings ha...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Joseph, Eric W., Pratilas, Christine A., Poulikakos, Poulikos I., Tadi, Madhavi, Wang, Weiqing, Taylor, Barry S., Halilovic, Ensar, Persaud, Yogindra, Xing, Feng, Viale, Agnes, Tsai, James, Chapman, Paul B., Bollag, Gideon, Solit, David B., Rosen, Neal
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2010
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930420/
https://ncbi.nlm.nih.gov/pubmed/20668238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008990107
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla