Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

RAF kinases are key players in the MAPK signaling pathway and are important targets for personalized cancer therapy. RAF dimerization is part of the physiological activation mechanism, together with phosphorylation, and is known to convey resistance to RAF inhibitors. Herein, molecular dynamics simu...

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發表在:Angew Chem Int Ed Engl
Main Authors: Jambrina, Pablo G., Rauch, Nora, Pilkington, Ruth, Rybakova, Katja, Nguyen, Lan K., Kholodenko, Boris N., Buchete, Nicolae‐Viorel, Kolch, Walter, Rosta, Edina
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2015
主題:
Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736688/
https://ncbi.nlm.nih.gov/pubmed/26644280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201509272
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