Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

RAF kinases are key players in the MAPK signaling pathway and are important targets for personalized cancer therapy. RAF dimerization is part of the physiological activation mechanism, together with phosphorylation, and is known to convey resistance to RAF inhibitors. Herein, molecular dynamics simu...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Jambrina, Pablo G., Rauch, Nora, Pilkington, Ruth, Rybakova, Katja, Nguyen, Lan K., Kholodenko, Boris N., Buchete, Nicolae‐Viorel, Kolch, Walter, Rosta, Edina
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736688/
https://ncbi.nlm.nih.gov/pubmed/26644280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201509272
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