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Differential Regulation of B-Raf Isoforms by Phosphorylation and Autoinhibitory Mechanisms
The B-Raf proto-oncogene encodes several isoforms resulting from alternative splicing in the hinge region upstream of the kinase domain. The presence of exon 8b in the B2-Raf(8b) isoform and exon 9b in the B3-Raf(9b) isoform differentially regulates B-Raf by decreasing and increasing MEK activating...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1800654/ https://ncbi.nlm.nih.gov/pubmed/17074813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01265-06 |
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