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Differential Regulation of B-Raf Isoforms by Phosphorylation and Autoinhibitory Mechanisms

The B-Raf proto-oncogene encodes several isoforms resulting from alternative splicing in the hinge region upstream of the kinase domain. The presence of exon 8b in the B2-Raf(8b) isoform and exon 9b in the B3-Raf(9b) isoform differentially regulates B-Raf by decreasing and increasing MEK activating...

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Bibliografske podrobnosti
Main Authors: Hmitou, Isabelle, Druillennec, Sabine, Valluet, Agathe, Peyssonnaux, Carole, Eychène, Alain
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800654/
https://ncbi.nlm.nih.gov/pubmed/17074813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01265-06
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