NRAS-driven melanoma: A RAF can hide another

Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, hi...

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Bibliografiske detaljer
Udgivet i:Mol Cell Oncol
Main Authors: Druillennec, Sabine, Pouponnot, Celio, Eychène, Alain
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706944/
https://ncbi.nlm.nih.gov/pubmed/29209643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1344758
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