RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

NRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was shown to be critical for various RAS-driven cancers, raising the question of the role of RAF proteins in NRAS-induced melanoma. Here, using conditional ablation of Raf genes in NRAS-induced mouse mela...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Dorard, Coralie, Estrada, Charlène, Barbotin, Céline, Larcher, Magalie, Garancher, Alexandra, Leloup, Jessy, Beermann, Friedrich, Baccarini, Manuela, Pouponnot, Celio, Larue, Lionel, Eychène, Alain, Druillennec, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437303/
https://ncbi.nlm.nih.gov/pubmed/28497782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15262
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados