RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

NRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was shown to be critical for various RAS-driven cancers, raising the question of the role of RAF proteins in NRAS-induced melanoma. Here, using conditional ablation of Raf genes in NRAS-induced mouse mela...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Dorard, Coralie, Estrada, Charlène, Barbotin, Céline, Larcher, Magalie, Garancher, Alexandra, Leloup, Jessy, Beermann, Friedrich, Baccarini, Manuela, Pouponnot, Celio, Larue, Lionel, Eychène, Alain, Druillennec, Sabine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437303/
https://ncbi.nlm.nih.gov/pubmed/28497782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15262
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi