RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

NRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was shown to be critical for various RAS-driven cancers, raising the question of the role of RAF proteins in NRAS-induced melanoma. Here, using conditional ablation of Raf genes in NRAS-induced mouse mela...

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Vydáno v:Nat Commun
Hlavní autoři: Dorard, Coralie, Estrada, Charlène, Barbotin, Céline, Larcher, Magalie, Garancher, Alexandra, Leloup, Jessy, Beermann, Friedrich, Baccarini, Manuela, Pouponnot, Celio, Larue, Lionel, Eychène, Alain, Druillennec, Sabine
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437303/
https://ncbi.nlm.nih.gov/pubmed/28497782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15262
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