Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation

Accumulating evidence points to inflammation as a promoter of carcinogenesis. MyD88 is an adaptor molecule in TLR and IL-1R signaling that was recently implicated in tumorigenesis through proinflammatory mechanisms. Here we have shown that MyD88 is also required in a cell-autonomous fashion for RAS-...

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Autors principals: Coste, Isabelle, Le Corf, Katy, Kfoury, Alain, Hmitou, Isabelle, Druillennec, Sabine, Hainaut, Pierre, Eychene, Alain, Lebecque, Serge, Renno, Toufic
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
Matèries:
Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947228/
https://ncbi.nlm.nih.gov/pubmed/20941850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42771
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