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Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation
Accumulating evidence points to inflammation as a promoter of carcinogenesis. MyD88 is an adaptor molecule in TLR and IL-1R signaling that was recently implicated in tumorigenesis through proinflammatory mechanisms. Here we have shown that MyD88 is also required in a cell-autonomous fashion for RAS-...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947228/ https://ncbi.nlm.nih.gov/pubmed/20941850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42771 |
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