Positive and negative regulation of Raf kinase activity and function by phosphorylation

Activating and inhibitory phosphorylation mechanisms play an essential role in regulating Raf kinase activity. Here we demonstrate that phosphorylation of C-Raf in the kinase activation loop (residues T491 and S494) is necessary, but not sufficient, for activation. C-Raf has additional activating ph...

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Опубликовано в::	EMBO J
Главные авторы:	Chong, Huira, Lee, Jeeyong, Guan, Kun-Liang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 2001
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125532/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.14.3716
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