Positive and negative regulation of Raf kinase activity and function by phosphorylation
Activating and inhibitory phosphorylation mechanisms play an essential role in regulating Raf kinase activity. Here we demonstrate that phosphorylation of C-Raf in the kinase activation loop (residues T491 and S494) is necessary, but not sufficient, for activation. C-Raf has additional activating ph...
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| Publicado no: | EMBO J |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125532/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.14.3716 |
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