Positive and negative regulation of Raf kinase activity and function by phosphorylation

Activating and inhibitory phosphorylation mechanisms play an essential role in regulating Raf kinase activity. Here we demonstrate that phosphorylation of C-Raf in the kinase activation loop (residues T491 and S494) is necessary, but not sufficient, for activation. C-Raf has additional activating ph...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Chong, Huira, Lee, Jeeyong, Guan, Kun-Liang
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2001
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125532/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.14.3716
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!