Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is often lethal because it is highly invasive and metastasizes rapidly. The actin-bundling protein fascin has been identified as a biomarker of invasive and advanced PDAC and regulates cell migration and invasion in vitro. We investigate...

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Detalhes bibliográficos
Main Authors: Li, Ang, Morton, Jennifer P., Ma, YaFeng, Karim, Saadia A., Zhou, Yan, Faller, William J., Woodham, Emma F., Morris, Hayley T., Stevenson, Richard P., Juin, Amelie, Jamieson, Nigel B., MacKay, Colin J., Carter, C. Ross, Leung, Hing Y., Yamashiro, Shigeko, Blyth, Karen, Sansom, Owen J., Machesky, Laura M.
Formato: Artigo
Idioma:Inglês
Publicado em: W.B. Saunders 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000441/
https://ncbi.nlm.nih.gov/pubmed/24462734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.01.046
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