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Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
BACKGROUND: Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate in these cells has been linked to the tum...
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| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BioMed Central
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4108060/ https://ncbi.nlm.nih.gov/pubmed/24280230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-1-12 |
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