Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

BACKGROUND: Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate in these cells has been linked to the tum...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Zheng, Liang, MacKenzie, Elaine D, Karim, Saadia A, Hedley, Ann, Blyth, Karen, Kalna, Gabriela, Watson, David G, Szlosarek, Peter, Frezza, Christian, Gottlieb, Eyal
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2013
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108060/
https://ncbi.nlm.nih.gov/pubmed/24280230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-1-12
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