Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces adaptive transcriptional upregulation of ASS1 and ASL in glioblastoma multiforme ex vivo cultures and cell lines. This adaptive transcriptional upregulation is blocked by neoplasia-specific CpG island methylatio...

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Main Authors: Syed, N, Langer, J, Janczar, K, Singh, P, Lo Nigro, C, Lattanzio, L, Coley, H M, Hatzimichael, E, Bomalaski, J, Szlosarek, P, Awad, M, O'Neil, K, Roncaroli, F, Crook, T
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563985/
https://ncbi.nlm.nih.gov/pubmed/23328665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.197
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