Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis

Tumours lacking argininosuccinate synthetase-1 (ASS1) are auxotrophic for arginine and sensitive to amino-acid deprivation. Here, we investigated the role of ASS1 as a biomarker of response to the arginine-lowering agent, pegylated arginine deiminase (ADI-PEG20), in lymphoid malignancies. Although A...

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Autori principali: Delage, B, Luong, P, Maharaj, L, O'Riain, C, Syed, N, Crook, T, Hatzimichael, E, Papoudou-Bai, A, Mitchell, T J, Whittaker, S J, Cerio, R, Gribben, J, Lemoine, N, Bomalaski, J, Li, C-F, Joel, S, Fitzgibbon, J, Chen, L-T, Szlosarek, P W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406582/
https://ncbi.nlm.nih.gov/pubmed/22764101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.83
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