Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase

BACKGROUND: Some cancers have been shown to lack expression of argininosuccinate synthetase (ASS), an enzyme required for the synthesis of arginine and a possible biomarker of sensitivity to arginine deprivation. Arginine deiminase (ADI) is a microbial enzyme capable of efficiently depleting periphe...

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Detalles Bibliográficos
Autores principales: Kelly, M P, Jungbluth, A A, Wu, B-W, Bomalaski, J, Old, L J, Ritter, G
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261683/
https://ncbi.nlm.nih.gov/pubmed/22134507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.524
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