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Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma
BACKGROUND: Arginine deiminase (ADI) is an enzyme that degrades arginine, an amino acid that is important for growth and development of normal and neoplastic cells. Melanoma cells are auxotrophic for arginine, because they lack argininosuccinatesynthetase (ASS), a key enzyme required for the synthes...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169197/ https://ncbi.nlm.nih.gov/pubmed/22864522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9862-2 |
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