Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

BACKGROUND: Arginine deiminase (ADI) is an enzyme that degrades arginine, an amino acid that is important for growth and development of normal and neoplastic cells. Melanoma cells are auxotrophic for arginine, because they lack argininosuccinatesynthetase (ASS), a key enzyme required for the synthes...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Ott, Patrick A., Carvajal, Richard D., Pandit-Taskar, Neeta, Jungbluth, Achim A., Hoffman, Eric W., Wu, Bor-Wen, Bomalaski, John S., Venhaus, Ralph, Pan, Linda, Old, Lloyd J., Pavlick, Anna C., Wolchok, Jedd D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169197/
https://ncbi.nlm.nih.gov/pubmed/22864522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9862-2
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker