Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

BACKGROUND: Arginine deiminase (ADI) is an enzyme that degrades arginine, an amino acid that is important for growth and development of normal and neoplastic cells. Melanoma cells are auxotrophic for arginine, because they lack argininosuccinatesynthetase (ASS), a key enzyme required for the synthes...

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Detalhes bibliográficos
Main Authors: Ott, Patrick A., Carvajal, Richard D., Pandit-Taskar, Neeta, Jungbluth, Achim A., Hoffman, Eric W., Wu, Bor-Wen, Bomalaski, John S., Venhaus, Ralph, Pan, Linda, Old, Lloyd J., Pavlick, Anna C., Wolchok, Jedd D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169197/
https://ncbi.nlm.nih.gov/pubmed/22864522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9862-2
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