Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

BACKGROUND: Arginine deiminase (ADI) is an enzyme that degrades arginine, an amino acid that is important for growth and development of normal and neoplastic cells. Melanoma cells are auxotrophic for arginine, because they lack argininosuccinatesynthetase (ASS), a key enzyme required for the synthes...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ott, Patrick A., Carvajal, Richard D., Pandit-Taskar, Neeta, Jungbluth, Achim A., Hoffman, Eric W., Wu, Bor-Wen, Bomalaski, John S., Venhaus, Ralph, Pan, Linda, Old, Lloyd J., Pavlick, Anna C., Wolchok, Jedd D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169197/
https://ncbi.nlm.nih.gov/pubmed/22864522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9862-2
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