Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

The ability to observe changes in molecular behavior during cancer cell invasion in vivo remains a major challenge to our understanding of the metastatic process. Here, we demonstrate for the first time an analysis of RhoA activity at a subcellular level using FLIM-FRET imaging in a live animal mode...

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Hlavní autoři: Timpson, Paul, McGhee, Ewan J., Morton, Jennifer P., von Kriegsheim, Alex, Schwarz, Juliane P., Karim, Saadia A., Doyle, Brendan, Quinn, Jean A., Carragher, Neil O., Edward, Mike, Olson, Michael F., Frame, Margaret C., Brunton, Valerie G., Sansom, Owen J., Anderson, Kurt I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033324/
https://ncbi.nlm.nih.gov/pubmed/21266354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2267
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