Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse

The small GTPase RhoA is a master regulator of signalling in cell-extracellular matrix interactions. RhoA signalling is critical to many cellular processes including migration, mechanotransduction, and is often disrupted in carcinogenesis. Investigating RhoA activity in a native tissue environment i...

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Publicat a:Small GTPases
Autors principals: Nobis, Max, Herrmann, David, Warren, Sean C., Strathdee, Douglas, Cox, Thomas R., Anderson, Kurt I., Timpson, Paul
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Commentary
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549666/
https://ncbi.nlm.nih.gov/pubmed/29457531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2018.1438024
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