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A RhoC Biosensor Reveals Differences in the Activation Kinetics of RhoA and RhoC in Migrating Cells

RhoA and RhoC GTPases share 92% amino acid sequence identity, yet play different roles in regulating cell motility and morphology. To understand these differences, we developed and validated a biosensor of RhoC activation (RhoC FLARE). This was used together with a RhoA biosensor to compare the spat...

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Main Authors: Zawistowski, Jon S., Sabouri-Ghomi, Mohsen, Danuser, Gaudenz, Hahn, Klaus M., Hodgson, Louis
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818223/
https://ncbi.nlm.nih.gov/pubmed/24224016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079877
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