Development of N-Methyl-(2-arylquinolin-4-yl)oxypropanamides as Leads to PET Radioligands for Translocator Protein (18 kDa)

Por Brouwer, Chad, Jenko, Kimberly, Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Publicado em 2014

The 5-HT(1A) Receptor PET Radioligand (11)C-CUMI-101 Has Significant Binding to α(1)-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region

Por Shrestha, Stal S., Liow, Jeih-San, Jenko, Kimberly, Ikawa, Masamichi, Zoghbi, Sami S., Innis, Robert B.
Publicado no J Nucl Med (2016)

Translocator Protein Ligands Based on N-Methyl-(quinolin-4-yl)oxypropanamides with Properties Suitable for PET Radioligand Development

Por Brouwer, Chad, Jenko, Kimberly J., Zoghbi, Sami S., Morse, Cheryl L., Innis, Robert B., Pike, Victor W.
Publicado no Eur J Med Chem (2016)

Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

Por Lohith, Talakad G, Osterweil, Emily K, Fujita, Masahiro, Jenko, Kimberly J, Bear, Mark F, Innis, Robert B
Publicado em 2013

On Quantitative Relationships Between Drug-Like Compound Lipophilicity and Plasma Free Fraction in Monkey and Human

Por ZOGHBI, SAMI S., ANDERSON, KACEY B., JENKO, KIMBERLY J., LUCKENBAUGH, DAVID A., INNIS, ROBERT B., PIKE, VICTOR W.
Publicado em 2011

Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofu...

Por Bao, Xiaofeng, Lu, Shuiyu, Liow, Jeih-San, Zoghbi, Sami S., Jenko, Kimberly J., Clark, David T., Gladding, Robert L., Innis, Robert B., Pike, Victor W.
Publicado em 2012

Human Brain Imaging and Radiation Dosimetry of (11)C-N-Desmethyl-Loperamide, a PET Radiotracer to Measure the Function of P-Glycoprotein

Por Seneca, Nicholas, Zoghbi, Sami S., Liow, Jeih-San, Kreisl, William, Herscovitch, Peter, Jenko, Kimberly, Gladding, Robert L., Taku, Andrew, Pike, Victor W., Innis, Robert B.
Publicado em 2009

Binding of a tritiated inverse agonist to cannabinoid CB(1) receptors is increased in patients with schizophrenia

Por Jenko, Kimberly J., Hirvonen, Jussi, Henter, Ioline D., Anderson, Kacey B., Zoghbi, Sami S., Hyde, Thomas M., Deep-Soboslay, Amy, Innis, Robert B., Kleinman, Joel E.
Publicado em 2012

In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB(1) receptors

Por Tsujikawa, Tetsuya, Zoghbi, Sami S., Hong, Jinsoo, Donohue, Sean R., Jenko, Kimberly J., Gladding, Robert L., Halldin, Christer, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Publicado em 2013

(11)C-CUMI-101, a PET Radioligand, Behaves as a Serotonin 1A Receptor Antagonist and Also Binds to α(1) Adrenoceptors in Brain

Por Shrestha, Stal Saurav, Liow, Jeih-San, Lu, Shuiyu, Jenko, Kimberly, Gladding, Robert L., Svenningsson, Per, Morse, Cheryl L., Zoghbi, Sami S., Pike, Victor W., Innis, Robert B.
Publicado no J Nucl Med (2014)

[carbonyl-(11)C]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(11)C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate rec...

Por Hong, Jinsoo, Lu, Shuiyu, Xu, Rong, Liow, Jeih-San, Woock, Alicia E., Jenko, Kimberly J., Gladding, Robert L., Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Publicado no Nucl Med Biol (2015)

Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer’s disease

Por Kreisl, William C., Lyoo, Chul Hyoung, Liow, Jeih-San, Snow, Joseph, Page, Emily, Jenko, Kimberly J., Morse, Cheryl L., Zoghbi, Sami S., Pike, Victor W., Turner, R. Scott, Innis, Robert B.
Publicado no Neurobiol Aging (2016)

Synthesis and Evaluation of Translocator 18 kDa Protein (TSPO) Positron Emission Tomography (PET) Radioligands with Low Binding Sensitivity to Human Single Nucleotide Polymorphism...

Por Zanotti-Fregonara, Paolo, Zhang, Yi, Jenko, Kimberly J., Gladding, Robert L., Zoghbi, Sami S., Fujita, Masahiro, Sbardella, Gianluca, Castellano, Sabrina, Taliani, Sabrina, Martini, Claudia, Innis, Robert B., Da Settimo, Federico, Pike, Victor W.
Publicado em 2014

(11)C-PBR28 binding to translocator protein increases with progression of Alzheimer’s disease

Por Kreisl, William C., Lyoo, Chul Hyoung, Liow, Jeih-San, Wei, Monica, Snow, Joseph, Page, Emily, Jenko, Kimberly J., Morse, Cheryl L., Zoghbi, Sami S., Pike, Victor W., Turner, R. Scott, Innis, Robert B.
Publicado no Neurobiol Aging (2016)

A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation

Por Kreisl, William C, Jenko, Kimberly J, Hines, Christina S, Hyoung Lyoo, Chul, Corona, Winston, Morse, Cheryl L, Zoghbi, Sami S, Hyde, Thomas, Kleinman, Joel E, Pike, Victor W, McMahon, Francis J, Innis, Robert B
Publicado em 2013

Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, Two Radioligands for Translocator Protein (18 kDa) in Human and Monkey: Implications for Positron Emission Tomographic Imaging...

Por Kreisl, William C., Fujita, Masahiro, Fujimura, Yota, Kimura, Nobuyo, Jenko, Kimberly J., Kannan, Pavitra, Hong, Jinsoo, Morse, Cheryl L., Zoghbi, Sami S., Gladding, Robert L., Jacobson, Steven, Oh, Unsong, Pike, Victor W., Innis, Robert B.
Publicado em 2009

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

Por Kreisl, William C., Lyoo, Chul Hyoung, McGwier, Meghan, Snow, Joseph, Jenko, Kimberly J., Kimura, Nobuyo, Corona, Winston, Morse, Cheryl L., Zoghbi, Sami S., Pike, Victor W., McMahon, Francis J., Turner, R. Scott, Innis, Robert B.
Publicado em 2013

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

Por Gershen, Leah P., Zanotti-Fregonara, Paolo, Dustin, Irene H., Liow, Jeih-San, Hirvonen, Jussi, Kreisl, William C., Jenko, Kimberly J., Inati, Sara K., Fujita, Masahiro, Morse, Cheryl L., Brouwer, Chad, Hong, Jinsoo S., Pike, Victor W., Zoghbi, Sami S., Innis, Robert B., Theodore, William H.
Publicado no JAMA Neurol (2015)