Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype

A known chemotype of H(3) receptor ligand was explored for development of a radioligand for imaging brain histamine subtype 3 (H(3)) receptors in vivo with positron emission tomography (PET), namely non-imidazole 2-aminoethylbenzofurans, represented by the compound (R)-(2-(2-(2-methylpyrrolidin-1-yl...

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Autori principali: Bao, Xiaofeng, Lu, Shuiyu, Liow, Jeih-San, Zoghbi, Sami S., Jenko, Kimberly J., Clark, David T., Gladding, Robert L., Innis, Robert B., Pike, Victor W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303611/
https://ncbi.nlm.nih.gov/pubmed/22313227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201690h
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