Development of N-Methyl-(2-arylquinolin-4-yl)oxypropanamides as Leads to PET Radioligands for Translocator Protein (18 kDa)

Por Brouwer, Chad, Jenko, Kimberly, Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Publicado em 2014

The 5-HT(1A) Receptor PET Radioligand (11)C-CUMI-101 Has Significant Binding to α(1)-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region

Por Shrestha, Stal S., Liow, Jeih-San, Jenko, Kimberly, Ikawa, Masamichi, Zoghbi, Sami S., Innis, Robert B.
Publicado no J Nucl Med (2016)

Evaluation of [(11)C]S14506 and [(18)F]S14506 in rat and monkey as agonist PET radioligands for brain 5-HT(1A) receptors

Por Lu, Shuiyu, Liow, Jeih-San, Zoghbi, Sami S., Hong, Jinsoo, Innis, Robert B., Pike, Victor W.
Publicado em 2010

Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches

Por Tonietto, Matteo, Rizzo, Gaia, Veronese, Mattia, Fujita, Masahiro, Zoghbi, Sami S, Zanotti-Fregonara, Paolo, Bertoldo, Alessandra
Publicado no J Cereb Blood Flow Metab (2015)

IN VIVO BINDING OF PROTOPORPHYRIN IX TO RAT TRANSLOCATOR PROTEIN IMAGED WITH POSITRON EMISSION TOMOGRAPHY

Por Ozaki, Harushige, Zoghbi, Sami S., Hong, Jinsoo, Verma, Ajay, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Publicado em 2010

N′-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N′-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl-D-aspartate (NMDA) Receptor: Synthesis a...

Por Naumiec, Gregory R., Jenko, Kimberley J., Zoghbi, Sami S., Innis, Robert B., Cai, Lisheng, Pike, Victor W.
Publicado no J Med Chem (2015)

Translocator Protein Ligands Based on N-Methyl-(quinolin-4-yl)oxypropanamides with Properties Suitable for PET Radioligand Development

Por Brouwer, Chad, Jenko, Kimberly J., Zoghbi, Sami S., Morse, Cheryl L., Innis, Robert B., Pike, Victor W.
Publicado no Eur J Med Chem (2016)

Quantification of Translocator Protein (18 kDa) in the Human Brain with PET and a Novel Radioligand, (18)F-PBR06

Por Fujimura, Yota, Zoghbi, Sami S., Simèon, Fabrice G., Taku, Andrew, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Publicado em 2009

On Quantitative Relationships Between Drug-Like Compound Lipophilicity and Plasma Free Fraction in Monkey and Human

Por ZOGHBI, SAMI S., ANDERSON, KACEY B., JENKO, KIMBERLY J., LUCKENBAUGH, DAVID A., INNIS, ROBERT B., PIKE, VICTOR W.
Publicado em 2011

Synthesis and Evaluation in Monkey of [(18)F]4-Fluoro-N-methyl-N-(4-(6- (methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX), a Promising Radioligand for PET Imaging of...

Por Xu, Rong, Zanotti-Fregonara, Paolo, Zoghbi, Sami S., Gladding, Robert L., Woock, Alicia, Innis, Robert B., Pike, Victor W
Publicado em 2013

Improved models for plasma radiometabolite correction and their impact on kinetic quantification in PET studies

Por Tonietto, Matteo, Veronese, Mattia, Rizzo, Gaia, Zanotti-Fregonara, Paolo, Lohith, Talakad G, Fujita, Masahiro, Zoghbi, Sami S, Bertoldo, Alessandra
Publicado no J Cereb Blood Flow Metab (2015)

Stroke incidentally identified using improved positron emission tomography for microglial activation

Por Kreisl, William C., Mbeo, Gilbert, Fujita, Masahiro, Zoghbi, Sami S., Pike, Victor W., Innis, Robert B., McArthur, Justin C.
Publicado em 2009

Effects of Ketoconazole on the Biodistribution and Metabolism of [(11)C]Loperamide and [(11)C]N-Desmethyl-loperamide in Wild-type and P-gp Knockout Mice

Por Seneca, Nicholas, Zoghbi, Sami S., Shetty, H. Umesha, Tuan, Edward, Kannan, Pavitra, Taku, Andrew, Innis, Robert B., Pike, Victor W.
Publicado em 2010

Comparison of (18)F- and (11)C-labeled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomography

Por Dickstein, Leah P., Zoghbi, Sami S., Fujimura, Yota, Imaizumi, Masao, Zhang, Yi, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Publicado em 2010

Quantification of metabotropic glutamate subtype 5 receptors in brain by an equilibrium method using (18)F-SP203

Por Kimura, Yasuyuki, Siméon, Fabrice G., Zoghbi, Sami S., Zhang, Yi, Hatazawa, Jun, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Publicado em 2011

Application of Calibrated Image Derived Input Function to a Clinical Protocol

Por Zanotti-Fregonara, Paolo, Lyoo, Chul Hyoung, Bar-Hen, Avner, Liow, Jeih-San, Zoghbi, Sami S, Fujita, Masahiro, Innis, Robert B.
Publicado em 2014

PET Measurement of the In Vivo Affinity of (11)C-(R)-Rolipram and the Density of Its Target, Phosphodiesterase-4, in the Brains of Conscious and Anesthetized Rats

Por Itoh, Tetsuji, Abe, Kohji, Zoghbi, Sami S., Inoue, Osamu, Hong, Jinsoo, Imaizumi, Masao, Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Publicado em 2009

[(11)C]Rhodamine-123: synthesis and biodistribution in rodents

Por Bao, Xiaofeng, Lu, Shuiyu, Liow, Jeih-San, Morse, Cheryl L., Anderson, Kacey, Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Publicado em 2012

Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifacts

Por Zanotti-Fregonara, Paolo, Liow, Jeih-San, Comtat, Claude, Zoghbi, Sami S., Zhang, Yi, Pike, Victor W., Fujita, Masahiro, Innis, Robert B.
Publicado em 2012

Kinetic Analysis in Healthy Humans of a Novel Positron Emission Tomography Radioligand to Image the Peripheral Benzodiazepine Receptor, a Potential Biomarker for Inflammation

Por Fujita, Masahiro, Imaizumi, Masao, Zoghbi, Sami S., Fujimura, Yota, Farris, Amanda G., Suhara, Tetsuya, Hong, Jinsoo, Pike, Victor W., Innis, Robert B.
Publicado em 2007